Gene
ctslb
- ID
- ZDB-GENE-980526-285
- Name
- cathepsin Lb
- Symbol
- ctslb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Localizes to extracellular region. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Is expressed in several structures, including ectoderm; hatching gland; hatching gland cell; hypoblast; and mesoderm. Orthologous to several human genes including CTSL (cathepsin L).
- Genome Resources
- Note
-
This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
- Comparative Information
-
- All Expression Data
- 170 figures from 112 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb15 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A7MCR8
|
335 | ||||||||
|
UniProtKB:P79722
|
336 | ||||||||
|
UniProtKB:A7MCR7
|
336 | ||||||||
|
UniProtKB:A8E587
|
336 | ||||||||
|
UniProtKB:A7MCM3
|
335 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctslb-201
(1)
|
Ensembl | 1,351 nt | ||
| mRNA |
ctslb-203
(1)
|
Ensembl | 1,289 nt | ||
| mRNA |
si:dkey-26g8.4-201
(1)
|
Ensembl | 1,348 nt | ||
| mRNA |
si:dkey-26g8.4-202
(1)
|
Ensembl | 308 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance