Gene
ctslb
- ID
- ZDB-GENE-980526-285
- Name
- cathepsin Lb
- Symbol
- ctslb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Located in extracellular region. Is expressed in several structures, including hatching gland; hatching gland cell; hypoblast; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L).
- Genome Resources
- Note
-
This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
- Comparative Information
-
- All Expression Data
- 171 figures from 113 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb15 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8E587 | InterPro | 336 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctslb-201
(1)
|
Ensembl | 1,351 nt | ||
| mRNA |
ctslb-203
(1)
|
Ensembl | 1,289 nt | ||
| mRNA |
si:dkey-26g8.4-201
(1)
|
Ensembl | 1,348 nt | ||
| mRNA |
si:dkey-26g8.4-202
(1)
|
Ensembl | 308 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-239J18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-269I1 | ZFIN Curated Data | |
| Encodes | EST | cb15 | Thisse et al., 2001 | |
| Encodes | EST | fb30g09 | ZFIN Curated Data | |
| Encodes | EST | fc13c06 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:123162 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174155 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174856 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:BC108031 (1) | 1320 nt | ||
| Genomic | GenBank:BX322603 | 191741 nt | ||
| Polypeptide | UniProtKB:A8E587 (1) | 336 aa |
- Comparative Orthology
- Alliance
- Chi, W.Y., Lee, G.H., Tang, M.J., Chen, B.H., Lin, W.L., Fu, T.F. (2024) Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation. BMC Biology. 22:146146
- Lee, J.J., Wang, T., Wiggins, K., Lu, P.N., Underwood, C., Ochenkowska, K., Samarut, E., Pollard, L.M., Flanagan-Steet, H., Steet, R. (2024) Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders. iScience. 27:109293109293
- McLeod, J.J., Rothschild, S.C., Francescatto, L., Kim, H., Tombes, R.M. (2023) Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):390-403
- Nakajima, H., Ishikawa, H., Yamamoto, T., Chiba, A., Fukui, H., Sako, K., Fukumoto, M., Mattonet, K., Kwon, H.B., Hui, S.P., Dobreva, G.D., Kikuchi, K., Helker, C.S.M., Stainier, D.Y.R., Mochizuki, N. (2023) Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish. Developmental Cell. 58(3):224-238.e7
- Boutillon, A., Escot, S., Elouin, A., Jahn, D., González-Tirado, S., Starruß, J., Brusch, L., David, N.B. (2022) Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Developmental Cell. 57(12):1529-1544.e5
- Chernyavskaya, Y., Zhang, X., Liu, J., Blackburn, J. (2022) Long-read sequencing of the zebrafish genome reorganizes genomic architecture. BMC Genomics. 23:116
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Cheng, Y.C., Wu, T.S., Huang, Y.T., Chang, Y., Yang, J.J., Yu, F.Y., Liu, B.H. (2021) Aflatoxin B1 interferes with embryonic liver development: involvement of p53 signaling and apoptosis in zebrafish. Toxicology. 458:152844
- Hatzold, J., Wessendorf, H., Pogoda, H.M., Bloch, W., Hammerschmidt, M. (2021) The Kunitz-type serine protease inhibitor Spint2 is required for cellular cohesion, coordinated cell migration and cell survival during zebrafish hatching gland development. Developmental Biology. 476:148-170
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
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