ZFIN is now using GRCz12tu for Genomic Data
Gene
ctslb
- ID
- ZDB-GENE-980526-285
- Name
- cathepsin Lb
- Symbol
- ctslb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz11
- Annotation Status
- Unknown
- Description
- Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Located in extracellular region. Is expressed in several structures, including hatching gland; hatching gland cell; hypoblast; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L).
- Genome Resources
- Note
-
This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
- Comparative Information
-
- All Expression Data
- 172 figures from 114 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb15 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR013128 | Peptidase C1A |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8E587 | InterPro | 336 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctslb-201
(1)
|
Ensembl | 1,351 nt | ||
| mRNA |
ctslb-203
(1)
|
Ensembl | 1,289 nt | ||
| mRNA |
si:dkey-26g8.4-201
(1)
|
Ensembl | 1,348 nt | ||
| mRNA |
si:dkey-26g8.4-202
(1)
|
Ensembl | 308 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance