PUBLICATION
Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin
- Authors
- Miyasaka, K.Y., Kida, Y.S., Sato, T., Minami, M., and Ogura, T.
- ID
- ZDB-PUB-070629-32
- Date
- 2007
- Source
- Proceedings of the National Academy of Sciences of the United States of America 104(27): 11274-11279 (Journal)
- Registered Authors
- Miyasaka, Kota, Ogura, Toshihiko
- Keywords
- gastrulation, heart, Wnt, zebrafish
- MeSH Terms
-
- Signal Transduction/genetics
- Humans
- Phosphoproteins/physiology*
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/physiology
- Wnt Proteins/physiology
- Glycine/biosynthesis
- Animals
- Carrier Proteins/biosynthesis
- Carrier Proteins/genetics
- Carrier Proteins/physiology*
- Adaptor Proteins, Signal Transducing/physiology*
- Cytoskeletal Proteins/physiology*
- Mesoderm/chemistry
- Mesoderm/cytology*
- Mesoderm/metabolism
- Cell Movement/physiology*
- Cysteine/biosynthesis
- Heart/embryology*
- Endoderm/chemistry
- Endoderm/cytology*
- Endoderm/metabolism
- Organ Specificity/genetics
- Cell Line
- Zebrafish Proteins/biosynthesis
- Zebrafish Proteins/deficiency
- Zebrafish Proteins/genetics
- Zebrafish Proteins/physiology*
- PubMed
- 17592114 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Miyasaka, K.Y., Kida, Y.S., Sato, T., Minami, M., and Ogura, T. (2007) Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. Proceedings of the National Academy of Sciences of the United States of America. 104(27):11274-11279.
Abstract
Zebrafish Csrp1 is a member of the cysteine- and glycine-rich protein (CSRP) family and is expressed in the mesendoderm and its derivatives. Csrp1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When csrp1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. Our data highlight Csrp1 as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping