Gene

apex1

ID
ZDB-GENE-040426-2761
Name
APEX nuclease (multifunctional DNA repair enzyme) 1
Symbol
apex1 Nomenclature History
Previous Names
  • hm:zehn1532
  • wu:fc13d11
  • zap1 (1)
  • zgc:66204
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA 3'-5' exodeoxyribonuclease activity; and phosphodiesterase I activity. Involved in several processes, including heart contraction; heart looping; and negative regulation of apoptotic process. Predicted to localize to nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).
Genome Resources
Note
None
Expression
All Expression Data
14 figures from 8 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apex1 Human Ortholog
No data available
Associated With apex1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR020847 AP endonuclease 1, binding site
Conserved_site IPR020848 AP endonuclease 1, conserved site
Domain IPR005135 Endonuclease/exonuclease/phosphatase
Family IPR004808 AP endonuclease 1
Homologous_superfamily IPR036691 Endonuclease/exonuclease/phosphatase superfamily
Domain Details Per Protein
Protein Length AP endonuclease 1 AP endonuclease 1, binding site AP endonuclease 1, conserved site Endonuclease/exonuclease/phosphatase Endonuclease/exonuclease/phosphatase superfamily
UniProtKB:H0WEZ7 220
UniProtKB:H0WEW8 105
UniProtKB:H0WFG1 116
UniProtKB:F1QTR9 341
UniProtKB:H0WED1 189
UniProtKB:H0WFB7 170
UniProtKB:A0A0R4IWF9 340
UniProtKB:A0A2R9YJQ0 310
UniProtKB:A0MTA1 310
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-apex1 polyclonal Rabbit
  • WB
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations