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Phenotype Figure Summary
Marker:
apex1
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Shin
et al.
, 2021
Fig. 2
apex1
kh2/kh2
whole organism decreased length, abnormal
Pei
et al.
, 2019
Fig. 1
WT + MO4-apex1
whole organism
apex1
expression decreased amount, abnormal
whole organism reactive oxygen species increased amount, abnormal
yolk syncytial layer nitric oxide increased amount, abnormal
Fig. 2
WT + MO4-apex1
brain morphology, abnormal
forebrain increased size, abnormal
forebrain morphology, abnormal
ventricular system morphology, abnormal
Fig. 3
WT + MO4-apex1
eye decreased size, abnormal
forebrain
fezf2
expression decreased amount, abnormal
forebrain
otx2b
expression decreased amount, abnormal
forebrain increased size, abnormal
hindbrain
pax2a
expression absent, abnormal
rhombomere 5
egr2a
expression decreased amount, abnormal
Fig. 4
WT + MO4-apex1
, 
WT + MO4-apex1 + MO4-tp53
whole organism
apex1
expression decreased amount, abnormal
whole organism
cdkn1a
expression increased amount, abnormal
whole organism
creb1a
expression decreased amount, abnormal
whole organism
egr2a
expression decreased amount, abnormal
whole organism
mdm2
expression increased amount, abnormal
whole organism
ogg1
expression decreased amount, abnormal
whole organism
polb
expression decreased amount, abnormal
whole organism
tp53
expression increased amount, abnormal
Fig. S4
WT + MO4-apex1
whole organism decreased life span, abnormal
Pei
et al.
, 2011
Fig. 3
WT + MO4-apex1
positive regulation of gene expression disrupted, abnormal
Fig. 5
WT + MO4-apex1
positive regulation of gene expression disrupted, abnormal
Wang
et al.
, 2006
Fig. 4
WT + MO4-apex1
apoptotic process increased occurrence, abnormal
cell death increased occurrence, abnormal
Fig. 6
WT + MO4-apex1
, 
WT + MO1-apex1 + MO2-apex1 + MO3-apex1
, 
twu34Tg + MO4-apex1
blood circulation disrupted, abnormal
brain deformed, abnormal
cell death increased occurrence, abnormal
eye decreased size, abnormal
heart deformed, abnormal
heart looping disrupted, abnormal
nucleate erythrocyte decreased amount, abnormal
pericardium edematous, abnormal
whole organism lethal (sensu genetics), abnormal
Fig. T1
WT + MO1-apex1 + MO2-apex1 + MO3-apex1
heart deformed, abnormal
heart looping disrupted, abnormal
pericardium edematous, abnormal
Fig. T2
WT + MO1-apex1 + MO2-apex1 + MO3-apex1
heart contraction decreased rate, abnormal
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