FIGURE

Figure 7.

ID

ZDB-FIG-260530-35

Publication

Pirzada et al., 2026 - Loss of U11/U12 spliceosome gene ZCRB1 leads to aberrant ciliogenesis and WNT signaling

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Figure 7.

Model depicting the role of ZCRB1 in ciliogenesis, WNT signaling, and vertebrate development.
Hypomorphic levels of ZCRB1/Zcrb1 lead to altered splicing of ciliary genes with minor introns leading to loss of primary cilia and coinciding hyperactivation of WNT signaling causing developmental abnormalities. The image was generated by BioRender software.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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