FIGURE

Figure S1.

ID

ZDB-FIG-260530-12

Publication

Pirzada et al., 2026 - Loss of U11/U12 spliceosome gene ZCRB1 leads to aberrant ciliogenesis and WNT signaling

Other Figures

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Figure S1.

Generation of CRISPR-Cas9-edited ZCRB1-heterozygous HEK293 cells.
(A) Schematic representation of sgRNAs 1 and 2 targeting exons 1 and 4 of ZCRB1. (B) IGV snapshots of whole-genome sequencing CRAM file alignments of ZCRB1-heterozygous cells compared with parental WT, depicting respective indels (shown in purple) because of ZCRB1 sgRNAs 1 and 2. (C) Gene dosage and functional consequences of CRISPR-Cas9–mediated editing of ZCRB1 along with gene coordinates and type of allelic mutations.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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