ZFIN ID: ZDB-GENE-990415-235
Gene Name: recombination activating gene 2
Gene Symbol: rag2
Sequence Ontology ID : SO:0000704

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Previous Name: zgc:136743

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 10 figures from 10 publications
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Adult (90d-730d, breeding adult)
  head kidney, kidney, ovarian follicle stage I, ovarian follicle stage II (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fb101 Indel Unknown Frameshift ZINC_FINGER_NUCLEASE
sa44245 Point Mutation Unknown Premature Stop ENU
PHENOTYPE
Data: 2 figures from 2 publications
Observed in: epithelial cell, fat cell, head kidney lymphocyte, head kidney mature B cell (all 11) expand
DISEASE ASSOCIATED WITH rag2 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Omenn syndrome Omenn syndrome 603554
severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive Severe combined immunodeficiency, B cell-negative 601457
Combined cellular and humoral immune defects with granulomas 233650
GENE ONTOLOGY
Ontology GO Term
Biological Process V(D)J recombination (more)
Cellular Component DNA recombinase complex (more)
Molecular Function protein binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004321 (1)
  • InterPro:IPR011011 (1)
  • InterPro:IPR011043 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR015915 (1)
  • InterPro:IPR025162 (1)
  • Pfam:PF03089 (1)
  • Pfam:PF13341 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA rag2-001 (1) 2682
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM rag2
    Tg(rag2:DsRed), Tg(rag2:EGFP), Tg(rag2:EGFP-bcl2a), Tg(rag2:EGFP-bcl2l1), Tg(rag2:EGFP-Hsa.ETV6-Hsa.RUNX1) (all 18) expand
    MARKER RELATIONSHIPS
    rag2Contained in: [BAC] CH211-256A21 (1) (order this)
    rag2Encodes: [EST] fc85e11 (1)
    [cDNA] MGC:136743 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131385 (1) 2635bp
    Genomic GenBank:AL935203 (1) 163572bp
    Select Tool
    Polypeptide UniProtKB:O13034 (1) 530aa
    Sequence Clusters UniGene:79818 (1)
    Sequence Information (all 18)
    OTHER rag2 GENE PAGES
  • Alliance (1)
  • Gene:30658 (1)
  • VEGA:OTTDARG00000022572 (1)
  • Ensembl(GRCz10):ENSDARG00000052121 (1)
  • ORTHOLOGY for rag2 (Chr: 25)
    CITATIONS (69)