FIGURE

Fig. 1

ID

ZDB-FIG-251114-1

Publication

Zhao et al., 2025 - β-Glucan pretreatment mitigates Edwardsiella piscicida-induced enteritis through restoring gut microbiota-associated tyrosine metabolism in zebrafish

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Fig. 1

BG pretreatment alleviates E. piscicida infection-induced enteritis in zebrafish. (A) Schematic model of BG-pretreatment and E. piscicida infection in zebrafish. (B) Histological analysis of posterior intestines in PBS- and BG-pretreated zebrafish during E. piscicida infection. Scale bar, 50 μm. (C) Histological index of zebrafish posterior intestines. (D) Statistical analysis of the histological score as indicated in panel B. (E) Transcriptional expression of tight junction protein-encode genes in posterior intestines of PBS- and BG-pretreated zebrafish during E. piscicida infection. Data are replicated with three independent experiments and shown as mean ± SD by a two-way ANOVA with multiple comparisons. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001; ns, not significant.

Expression Data

Genes:	cldn1 cldn2 cldna tjp1a
Fish:	AB
Conditions:	chemical treatment by injection: (1->3,1->6)-beta-D-glucan bacterial treatment by injection: Edwardsiella piscicida, chemical treatment by injection: (1->3,1->6)-beta-D-glucan bacterial treatment by injection: Edwardsiella piscicida
Anatomical Term:	posterior intestine
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by injection: (1->3,1->6)-beta-D-glucan bacterial treatment by injection: Edwardsiella piscicida, chemical treatment by injection: (1->3,1->6)-beta-D-glucan bacterial treatment by injection: Edwardsiella piscicida
Observed In:	intestinal epithelium intestinal villus intestine inflammatory response intestine lumen posterior intestine
Stage:	Adult

Phenotype Detail

Acknowledgments

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