Gene

tjp1a

ID

ZDB-GENE-031001-2

Name

tight junction protein 1a

Symbol

tjp1a Nomenclature History

Previous Names

tjp1.1 (1)
tjp1
zo-1 (1)
cb817 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Involved in pigmentation. Localizes to bicellular tight junction. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

48 figures from 27 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb817 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tjp1a Human Ortholog

No data available

Associated With tjp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000906	ZU5 domain
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR035597	ZO-1, SH3 domain
Family	IPR005417	Tight junction protein ZO
Family	IPR005418	Tight junction protein ZO-1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Tight junction protein ZO	Tight junction protein ZO-1	ZO-1, SH3 domain	ZU5 domain
UniProtKB:A0A2R8Q396 InterPro	1680
UniProtKB:A0A1D5NSI3 InterPro	16
UniProtKB:A0A2L2BH75 InterPro	1624
UniProtKB:A0A2R8QMK9 InterPro	1689
UniProtKB:X1WG30 InterPro	103
UniProtKB:A0A1D5NT08 InterPro	69
UniProtKB:A0A1D5NSN9 InterPro	345
UniProtKB:X1WGR1 InterPro	26
UniProtKB:E9QET4 InterPro	1624
UniProtKB:E7F2W2 InterPro	1633
UniProtKB:A0A1D5NS61 InterPro	147
UniProtKB:A0A1D5NSJ0 InterPro	141

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	tjp1a-202 (1) Ensembl	6999 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-203 (1) Ensembl	676 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-204 (1) Ensembl	612 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-205 (1) Ensembl	485 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-206 (1) Ensembl	1035 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-207 (1) Ensembl	544 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-209 (1) Ensembl	206 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tjp1a-210 (1) Ensembl	784 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tjp1a-004 (1) Ensembl	751 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tjp1	monoclonal	tjp1a tjp1b	IgG1 , k	Mouse	IHC	Life Technologies (Invitrogen) Thermo Fisher Scientific (Lab Vision)	209
Ab2-tjp1	polyclonal	tjp1a		Rabbit	IHC	Life Technologies (Invitrogen)	24
Ab5-tjp1a	polyclonal	tjp1a		Rabbit	IHC		2
Ab4-tjp1a	polyclonal	tjp1a		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations