PUBLICATION
β-Glucan pretreatment mitigates Edwardsiella piscicida-induced enteritis through restoring gut microbiota-associated tyrosine metabolism in zebrafish
- Authors
- Zhao, Y., Mei, X., Liu, Q., Yang, D., Wang, Z.
- ID
- ZDB-PUB-250914-7
- Date
- 2025
- Source
- Fish & shellfish immunology : 110873110873 (Journal)
- Registered Authors
- Yang, Dahai
- Keywords
- Edwardsiella piscicida, Fish enteritis, Microbiota, Tyrosine metabolism, β-Glucan
- MeSH Terms
-
- RNA, Ribosomal, 16S/analysis
- Animal Feed/analysis
- Gastrointestinal Microbiome*/drug effects
- Zebrafish*
- beta-Glucans*/administration & dosage
- beta-Glucans*/pharmacology
- Enterobacteriaceae Infections*/immunology
- Enterobacteriaceae Infections*/microbiology
- Enterobacteriaceae Infections*/prevention & control
- Enterobacteriaceae Infections*/veterinary
- Fish Diseases*/immunology
- Fish Diseases*/microbiology
- Fish Diseases*/prevention & control
- Tyrosine*/metabolism
- Animals
- Edwardsiella/physiology
- Enteritis*/immunology
- Enteritis*/microbiology
- Enteritis*/prevention & control
- Enteritis*/veterinary
- PubMed
- 40945627 Full text @ Fish Shellfish Immunol.
Citation
Zhao, Y., Mei, X., Liu, Q., Yang, D., Wang, Z. (2025) β-Glucan pretreatment mitigates Edwardsiella piscicida-induced enteritis through restoring gut microbiota-associated tyrosine metabolism in zebrafish. Fish & shellfish immunology. :110873110873.
Abstract
Edwardsiella piscicida infection is one of the major constraints inducing bacterial enteritis, which would cause intestinal barrier damage, hyperinflammation and even mortality of aquatic fish, incurring substantial economic losses in aquaculture. β-Glucan is increasingly reported as therapeutic immunostimulant in various infectious diseases, while the role of β-glucan in mitigating bacterial enteritis remains unclear. Herein, through establishing a β-glucan pretreatment and Edwardsiella piscicida infection model in adult zebrafish, we demonstrate that β-glucan pretreatment alleviates E. piscicida-induced intestinal barrier damage. Moreover, we perform the integrated analysis of 16S rRNA sequencing and untargeted metabolomics, and found that β-glucan pretreatment could restore gut microbiota and enhance metabolic flux from phenylalanine to tyrosine, indicating the strong correlation between microbiota and metabolism. In addition, we reveal that microbiota homeostasis-associated tyrosine maintenance is critical for protecting the bacterial enteritis through exogenous metabolite supplementation and pharmacological inhibition experiments in vivo. Taken together, our findings highlight a β-glucan-engaged intestinal microbiota-metabolism-immune axis, and provide mechanistic basis for application of β-glucan to prevent bacterial enteritis in aquaculture.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping