ZFIN ID: ZDB-GENE-010328-11
Gene Name: claudin 1
Gene Symbol: cldn1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: cldn19 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Predicted to localize to the bicellular tight junction; integral component of membrane; and plasma membrane. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Is expressed in eye and ovary. Orthologous to human CLDN1 (claudin 1).
Genome Resources: Alliance (1),  Gene:81590 (1),  Ensembl(GRCz11):ENSDARG00000040045 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cldn1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 607626
DISEASE ASSOCIATED WITH cldn1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component bicellular tight junction (more)
Molecular Function structural molecule activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR003548 Claudin-1
Family IPR004031 PMP-22/EMP/MP20/Claudin superfamily
Family IPR006187 Claudin
Conserved_site IPR017974 Claudin, conserved site
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cldn1 No data available
MARKER RELATIONSHIPS
cldn1 Encodes: [cDNA] MGC:109867 (1), MGC:114028 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131770 (1)
Genomic GenBank:CABZ01111921 (1) 1533 bp
Polypeptide UniProtKB:F1R6Z2 (1) 210 aa
Sequence Information (all 17)
ORTHOLOGY for cldn1 ( Chr: 2 )
CITATIONS (29)