Gene

cldn1

ID
ZDB-GENE-010328-11
Name
claudin 1
Symbol
cldn1 Nomenclature History
Previous Names
  • cldn19 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to localize to bicellular tight junction and plasma membrane. Is expressed in eye; gill; integument; and ovary. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cldn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis 607626
Associated With cldn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017974 Claudin, conserved site
Family IPR003548 Claudin-1
Family IPR004031 PMP-22/EMP/MP20/Claudin superfamily
Family IPR006187 Claudin
Domain Details Per Protein
Protein Length Claudin Claudin-1 Claudin, conserved site PMP-22/EMP/MP20/Claudin superfamily
UniProtKB:Q90XQ8 210
UniProtKB:F1R6Z2 210
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Kollmar, et al. 2001. (Proc. Natl. Acad. Sci. 98:10196-10201.; ZDB-PUB-010912-21) originally suggested this gene was the ortholog of human CLDN19 based on amino acid sequence similarity. Subsequent analysis suggests it is the ortholog of human CLDN1 and mouse Cldn1.
Citations