Gene
cldn2
- ID
- ZDB-GENE-040912-26
- Name
- claudin 2
- Symbol
- cldn2 Nomenclature History
- Previous Names
-
- zgc:92260
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in brain; eye; gonad; immune system; and liver. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 29. Orthologous to several human genes including CLDN14 (claudin 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92260 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa43695 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Azoospermia, obstructive, with nephrolithiasis | 301060 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Claudin | Claudin, conserved site | PMP-22/EMP/MP20/Claudin |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BHN3 | InterPro | 270 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-38K9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92260 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004559 (1) | 1873 nt | ||
| Genomic | GenBank:BX530030 (2) | 180154 nt | ||
| Polypeptide | UniProtKB:A0A8M2BHN3 (1) | 270 aa |
- El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
- Yang, Y., Du, H., Pan, Y., Gong, P., Yang, Y., Wu, F., Pan, D., Xie, W., Fu, Z., Ni, Y. (2023) Bifidobacterium animalis subsp. lactis LKM512 alleviates inflammatory bowel disease in larval zebrafish by reshaping microbiota. Biological & pharmaceutical bulletin. 46(12):1706-1713
- van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., Schaaf, M. (2020) Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Frontiers in immunology. 11:727
- Hsu, A.Y., Gurol, T., Sobreira, T.J.P., Zhang, S., Moore, N., Cai, C., Zhang, Z.Y., Deng, Q. (2018) Development and Characterization of an Endotoxemia Model in Zebra Fish. Frontiers in immunology. 9:607
- Philip, A.M., Wang, Y., Mauro, A., El-Rass, S., Marshall, J.C., Lee, W.L., Slutsky, A.S., dos Santos, C.C., Wen, X.Y. (2017) Development of a zebrafish sepsis model for high-throughput drug discovery. Molecular medicine (Cambridge, Mass.). 23:134-148
- Shu, Y., Lou, Q., Dai, Z., Dai, X., He, J., Hu, W., Yin, Z. (2016) The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models. Scientific Reports. 6:18597
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- McKee, R., Gerlach, G.F., Jou, J., Cheng, C.N., Wingert, R.A. (2014) Temporal and spatial expression of tight junction genes during zebrafish pronephros development. Gene expression patterns : GEP. 16:104-113
- Baltzegar, D.A., Reading, B.J., Brune, E.S., and Borski, R.J. (2013) Phylogenetic revision of the claudin gene family. Marine genomics. 11:17-26
- Kumai, Y., Bahubeshi, A., Steele, S., and Perry, S.F. (2011) Strategies for maintaining Na+ balance in zebrafish (Danio rerio) during prolonged exposure to acidic water. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 160(1):52-62
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