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- Wu et al., 2025 - Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
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Conditional inactivation of Pu.1 leads to chronic elimination of microglia in the spinal cord and retina of adult zebrafish. (A) Representative images of the retina cross section of adult pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 3 mpi. (B) Quantification of the percentage of DsRed+ microglia in the retina of adult pu.1KI/+;Tg(coro1a:CreER) (n=4) and pu.1KI/Δ839;Tg(coro1a:CreER) (n=4) fish at 3 mpi. (C) Representative images of the spinal cord cross section of adult pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 3 mpi. (D) Quantification of the percentage of DsRed+ microglia in the spinal cord of adult pu.1KI/+;Tg(coro1a:CreER) (n=4) and pu.1KI/Δ839;Tg(coro1a:CreER) (n=4) fish at 3 mpi. **p<0.01; ****p<0.0001. |