Fig. 3
- ID
- ZDB-FIG-250808-47
- Publication
- Wu et al., 2025 - Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals
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pu.1-deficient microglia were chronically eliminated in mosaic condition. (A) The experimental setup for pu.1 conditional knockout in adult zebrafish and the representative images of midbrain cross section of pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 8 days post 4-OHT injection (dpi). (B) Quantification of the number of DsRed+ microglia on the midbrain cross section of pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 2 dpi (n=3) and 8 dpi (n=4). (C) Quantification of the proportion of DsRed+ microglia on the midbrain cross section of pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 2 dpi (n=3) and 8 dpi (n=4). (D) The experimental setup for pu.1 conditional knockout in adult zebrafish and the representative images of midbrain cross section of pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 3 months post 4-OHT injection (mpi). (E) Quantification of the number of DsRed+ microglia on the midbrain cross section of pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 1 mpi (n=3) and 3 mpi (n=4). (F) Quantification of the proportion of DsRed+ microglia on the midbrain cross section of pu.1KI/+;Tg(coro1a:CreER) and pu.1KI/Δ839;Tg(coro1a:CreER) fish at 1 mpi (n=3) and 3 mpi (n=4). n.s.=not significant, p>0.05; **p<0.01; ****p<0.0001. |