FIGURE

Fig. 4

ID

ZDB-FIG-250609-115

Publication

Lee et al., 2025 - Transforming growth factor-β receptor I kinase plays a crucial role in oligodendrocyte regeneration after demyelination

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Fig. 4

TGF-βRI kinase inhibitor downregulates TGF-β1 and TGF-βRI mRNA expression levels post-demyelination. (A) Schematic representation of the treatment protocols using Tg(mbpa:qf2;quas:epntr-p2a-mcherry) zebrafish larvae. (B-E) RT-qPCR results for tgf-β1a, tgf-β1b, tgf-βr1a, and tgf-βr1b mRNA expression. The experiment was repeated thrice. The data are presented as the mean ± SD; n ≥ 20 independent experiments. P-values were calculated using one-way ANOVA followed by Tukey’s test. Significance is indicated by *P < 0.05, **P < 0.01, and ***P < 0.001 vs. DMSO; #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. MTZ 18 h + E3 or MTZ 18 h + AZ.

Expression Data

Genes:	tgfb1a tgfb1b tgfbr1a tgfbr1b
Fish:	km18Tg; km19Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: TGFbeta receptor antagonist chemical treatment by environment: metronidazole
Anatomical Term:	whole organism
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	km18Tg; km19Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: TGFbeta receptor antagonist chemical treatment by environment: metronidazole
Observed In:	whole organism
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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