FIGURE

Fig. 7

ID

ZDB-FIG-250609-118

Publication

Lee et al., 2025 - Transforming growth factor-β receptor I kinase plays a crucial role in oligodendrocyte regeneration after demyelination

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Fig. 7

TGF-βRI kinase inhibitor promotes oligodendrocyte progenitor cell proliferation early after demyelination. Confocal images of a transverse section of the spinal cord of demyelinated zebrafish larvae at 2 and 4 days post-treatment (dpt). Sections are labeled for SOX10 and BrdU; the enlarged images show SOX10+BrdU+-cells. The graphs show the number of BrdU+-cells among the SOX10+-cells 2 and 4 dpt; the double-positive cells are counted in 10 sections per larva. The experiment was repeated thrice. The data are presented as the mean ± SD; n ≥ 8 independent experiments. P-values were calculated using one-way ANOVA followed by Tukey’s test. Significance is indicated by **P < 0.01 and ***P < 0.001 vs. DMSO; ###P < 0.001 vs. MTZ 18 h + E3 or MTZ 18 h + AZ. ns: not significant. Scale bar: 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	km18Tg; km19Tg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: TGFbeta receptor antagonist chemical treatment by environment: metronidazole
Observed In:	spinal cord glioblast (sensu Vertebrata)
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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