ZFIN ID: ZDB-GENE-030618-1
Gene Name: transforming growth factor, beta 1a
Gene Symbol: tgfb1a    Nomenclature History

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Previous Names: tgfb1 (1), ai39657, wu:fb13a07 (1), xx:ai39657

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Involved in hematopoietic stem cell differentiation; otolith development; and posterior lateral line development. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; digestive system; epidermis; fin; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; aphthous stomatitis; artery disease (multiple); bone disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
Genome Resources: Alliance (1),  Gene:359834 (1),  Ensembl(GRCz11):ENSDARG00000041502 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16296 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39023 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39024 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42471 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tsu1td Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    tsu5td Small Deletion Exon 1 Frameshift, Premature Stop TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • tsu8td Small Deletion Exon 1 Frameshift, Premature Stop TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tgfb1a
    2
    CRISPR2-tgfb1a
    2
    MO1-tgfb1a N/A 1
    MO2-tgfb1a N/A 1
    MO3-tgfb1a N/A 1
    MO4-tgfb1a N/A 1
    MO5-tgfb1a N/A 1
    MO6-tgfb1a N/A 1
    TALEN1-tgfb1a 1
    DISEASE ASSOCIATED WITH tgfb1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Camurati-Engelmann disease Alliance Camurati-Engelmann disease 131300
    cystic fibrosis Alliance {Cystic fibrosis lung disease, modifier of} 219700
    Inflammatory bowel disease, immunodeficiency, and encephalopathy 618213
    DISEASE ASSOCIATED WITH tgfb1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tgfb1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(fabp10a:LEXPR-2A-mCherry-LEXOP-tgfb1a) fabp10a 2ALEXOPLEXPRmCherrytgfb1a Danio rerio 1 2
    MARKER RELATIONSHIPS
    tgfb1a Encodes: [EST] eu837 (1), fb13a07
    [cDNA] MGC:194011 (1), MGC:194018 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_182873 (1)
    Genomic GenBank:CABZ01086045 (1) 27539 nt
    Select Tool
    Polypeptide UniProtKB:F1R741 (1) 377 aa
    Sequence Information (all 21)
    ORTHOLOGY for tgfb1a ( Chr: 15 )
    CITATIONS (131)