FIGURE

Fig. 6

ID

ZDB-FIG-250609-117

Publication

Lee et al., 2025 - Transforming growth factor-β receptor I kinase plays a crucial role in oligodendrocyte regeneration after demyelination

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Fig. 6

TGF-βRI kinase inhibitor increases the number of oligodendrocyte progenitor cells early after demyelination. (A) Lateral views of the spinal cord of transgenic zebrafish larvae at 1 and 4 days post-treatment (dpt), anterior to the left and dorsal to the top. In the spinal cord, fluorescence indicates sox10+-OPCs (arrowhead) and mbpa+sox10+-mature oligodendrocytes (OLs) (arrow) in each 2-somite area. (B-E) Numbers of sox10+- and mbpa+sox10+-cells in each 4-somite area 1–4 dpt. The experiment was repeated thrice. The data are presented as the mean ± SD; n ≥ 8 independent experiments. P-values were calculated using one-way ANOVA followed by Tukey’s test. Significance is indicated by *P < 0.05 and ***P < 0.001 vs. DMSO; #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. MTZ 18 h + E3 or MTZ 18 h + AZ. ns: not significant. Scale bar: 200 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gl24Tg; km18Tg; km19Tg; nkuasgfp1aTg
Conditions:	chemical treatment by environment: metronidazole chemical treatment by environment: TGFbeta receptor antagonist chemical treatment by environment: metronidazole
Observed In:	spinal cord glioblast (sensu Vertebrata) spinal cord oligodendrocyte
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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