ZFIN ID: ZDB-GENE-091028-1
Gene Name: transforming growth factor, beta 1b
Gene Symbol: tgfb1b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have cytokine activity; type II transforming growth factor beta receptor binding activity; and type III transforming growth factor beta receptor binding activity. Involved in JNK cascade and hematopoietic stem cell differentiation. Predicted to localize to extracellular space. Is expressed in cardiovascular system; head; hematopoietic system; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; aphthous stomatitis; artery disease (multiple); bone disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1).
Genome Resources: Alliance (1),  Gene:563884 (1),  Ensembl(GRCz11):ENSDARG00000034895 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns354 Indel Unknown Unknown CRISPR
ihb421 Insertion Exon 2 Unknown CRISPR
sa3109 Point Mutation Unknown Premature Stop ENU
zf2126 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tgfb1b 1
CRISPR2-tgfb1b
2
CRISPR3-tgfb1b
2
CRISPR4-tgfb1b 1
CRISPR5-tgfb1b 1
MO1-tgfb1b N/A 1
MO2-tgfb1b N/A 1
DISEASE ASSOCIATED WITH tgfb1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Camurati-Engelmann disease Alliance Camurati-Engelmann disease 131300
cystic fibrosis Alliance {Cystic fibrosis lung disease, modifier of} 219700
Inflammatory bowel disease, immunodeficiency, and encephalopathy 618213
DISEASE ASSOCIATED WITH tgfb1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hematopoietic stem cell differentiation (more)
Cellular Component extracellular region (more)
Molecular Function growth factor activity (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tgfb1b-201 (1)    Ensembl 1403
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tgfb1b
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
tg(5xuas-hsp70l:tgfb1b-2a-hsa.histh2bj-gfp) hsp70lUAS 2AGFPtgfb1b Danio rerioHomo sapiens 1 1
tg(tgfb1b:gfp) tgfb1b GFP Danio rerio 1 1
MARKER RELATIONSHIPS
tgfb1b Contained in: [BAC] CH211-51A20 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_687246 (1)
Genomic GenBank:AL929321 (1) 193470 nt
Select Tool
Polypeptide UniProtKB:E9QHW0 (1) 379 aa
Sequence Information (all 6)
ORTHOLOGY for tgfb1b ( Chr: 21 )
CITATIONS (35)