FIGURE

Fig. 1

ID

ZDB-FIG-250519-6

Publication

Semenova et al., 2025 - Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

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Fig. 1

Differentially expressed genes in xrcc1 crispants. (a) Genes that were significantly changed in both gRNA-t1/2 and gRNA-t5/6 crispants. Axes show − 1×log₂ (fold change) in crispants compared to controls. Dot size indicates log₁₀(mean false discovery rate). Lens proteins are highlighted in orange. (b) Normalized counts in controls (ctl) and crispants (mut) for selected genes that were differentially expressed in both experiments.

Expression Data

Genes:	cryaa cryba1a crybb1l2 lctla tp53 ttll4 xrcc1
Fish:	TL TL + CRISPR2-xrcc1 + CRISPR3-xrcc1 TL + CRISPR6-xrcc1 + CRISPR7-xrcc1
Knockdown Reagents:	CRISPR2-xrcc1 CRISPR3-xrcc1 CRISPR6-xrcc1 CRISPR7-xrcc1
Anatomical Term:	head
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + CRISPR2-xrcc1 + CRISPR3-xrcc1 TL + CRISPR6-xrcc1 + CRISPR7-xrcc1
Knockdown Reagents:	CRISPR2-xrcc1 CRISPR3-xrcc1 CRISPR6-xrcc1 CRISPR7-xrcc1
Observed In:	head
Stage:	Day 6

Phenotype Detail

Acknowledgments

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