FIGURE

Fig. 3

ID

ZDB-FIG-250519-8

Publication

Semenova et al., 2025 - Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

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Fig. 3

Rescue of xrcc1 crispant cerebellar phenotype by parp1 deletion. (a) Volume of the lateral cerebellar plate (LCeP) in controls (ctl) and parp1 crispants (parp). N = 13,12. (b) Volume of the LCeP in control larvae (ctl), xrcc1 crispants (xrcc ; gRNA-t1/2) and xrcc1, parp1 double crispants (dbl ; xrcc1 gRNA-t1/2 and parp1 gRNA-t6/8). N = 16,14,12 respectively. * t-test p < 0.01. (c) qPCR for tp53 in controls (ctl), xrcc1 crispants (xrcc) and xrcc1, parp1 double crispants (dbl). * t-test p = 0.018, ** p = 0.001.

Expression Data

Gene:	tp53
Fish:	TL TL + CRISPR2-xrcc1 + CRISPR3-xrcc1 TL + CRISPR14-parp1 + CRISPR16-parp1 + CRISPR2-xrcc1 + CRISPR3-xrcc1
Knockdown Reagents:	CRISPR2-xrcc1 CRISPR3-xrcc1 CRISPR14-parp1 CRISPR16-parp1
Anatomical Term:	head
Stage:	Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + CRISPR2-xrcc1 + CRISPR3-xrcc1 TL + CRISPR14-parp1 + CRISPR16-parp1 TL + CRISPR14-parp1 + CRISPR16-parp1 + CRISPR2-xrcc1 + CRISPR3-xrcc1
Knockdown Reagents:	CRISPR2-xrcc1 CRISPR3-xrcc1 CRISPR14-parp1 CRISPR16-parp1
Observed In:	cerebellar plate head
Stage:	Day 6

Phenotype Detail

Acknowledgments

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