ZFIN is now using GRCz12tu for Genomic Data
Gene
xrcc1
- ID
- ZDB-GENE-040822-30
- Name
- X-ray repair complementing defective repair in Chinese hamster cells 1
- Symbol
- xrcc1 Nomenclature History
- Previous Names
-
- zgc:91996
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable damaged DNA binding activity. Predicted to be involved in base-excision repair. Predicted to be located in chromosome. Predicted to be active in nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); central nervous system cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and liver disease (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Semenova et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 26 | Alliance | ?Spinocerebellar ataxia, autosomal recessive 26 | 617633 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BRCT domain | BRCT domain superfamily | DNA-repair protein Xrcc1, N-terminal | Galactose-binding-like domain superfamily | XRCC1, first (central) BRCT domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q68EG6 | InterPro | 615 | |||||
| UniProtKB:F1QXI2 | InterPro | 617 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers