Gene

xrcc1

ID

ZDB-GENE-040822-30

Name

X-ray repair complementing defective repair in Chinese hamster cells 1

Symbol

xrcc1 Nomenclature History

Previous Names

zgc:91996

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable damaged DNA binding activity. Predicted to be involved in base-excision repair. Predicted to act upstream of or within single strand break repair. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); respiratory system cancer (multiple); and urinary system cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:91996 (1 image)
IMAGE:7159381 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With xrcc1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive spinocerebellar ataxia 26	Alliance	?Spinocerebellar ataxia, autosomal recessive 26	617633

Associated With xrcc1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001357	BRCT domain
Domain	IPR002706	DNA-repair protein Xrcc1, N-terminal
Domain	IPR045080	XRCC1, first (central) BRCT domain
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR036420	BRCT domain superfamily