Gene

cryaa

ID
ZDB-GENE-020508-1
Name
crystallin, alpha A
Symbol
cryaa Nomenclature History
Previous Names
  • [a]A-crystallin (1)
  • hspb4
  • wu:fc06h04
  • zgc:92036
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits unfolded protein binding activity. Involved in lens development in camera-type eye. Predicted to localize to cytoplasm. Is expressed in eye; lens; and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Orthologous to several human genes including CRYAA2 (crystallin alpha A2).
Genome Resources
Note
None
Expression
All Expression Data
34 figures from 21 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cryaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 9 multiple types Alliance Cataract 9, multiple types 604219
Associated With cryaa Via Experimental Models
Human Disease Fish Conditions Citations
cataract cryaavu532/vu532 standard conditions Zou et al., 2015
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002068 Alpha crystallin/Hsp20 domain
Domain IPR003090 Alpha-crystallin, N-terminal
Family IPR001436 Alpha crystallin/Small heat shock protein, animal type
Family IPR012274 Alpha-crystallin, subunit A
Homologous_superfamily IPR008978 HSP20-like chaperone
Domain Details Per Protein
Protein Length Alpha crystallin/Hsp20 domain Alpha-crystallin, N-terminal Alpha crystallin/Small heat shock protein, animal type Alpha-crystallin, subunit A HSP20-like chaperone
UniProtKB:Q8UUZ6 173
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cryaa polyclonal Rabbit
  • IHC
  • WB
5
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations