FIGURE

Fig. 7

ID

ZDB-FIG-250428-66

Publication

D'Aprile et al., 2025 - Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment

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Fig. 7

Resistant cells treated with TMZ, guanosine and inosine reshape their mitochondrial activity.

a Representative micrographs of TMRM staining in CTRL, TMZ-treated and TMZ + GUA + INO-treated cells for U-251 MG S, U-251 MG R, T98-G. Scale bar = 10 μm. b–d Correlated quantification between MFI TMRM in FC over CTRL and % of occupancy for U-251 MG S (b), U-251 MG R (c) and T98- G (d). For U-251 MG S, CTRL: n = 49 cells from 4 biological replicates; TMZ: n = 46 cells from 4 biological replicates; TMZ + GUA + INO: n = 45 cells from 4 biological replicates. For U-251 MG R, CTRL: n = 46 cells from 4 biological replicates; TMZ: n = 33 cells from 4 biological replicates; TMZ + GUA + INO: n = 38 cells from 4 biological replicates. For T98-G, CTRL: n = 25 cells from 4 biological replicates; TMZ: n = 31 cells from 4 biological replicates; TMZ + GUA + INO: n = 27 cells from 4 biological replicates. Data are shown via scatter plots as mean ± SD. CTRL control, FC fold change, GUA guanosine, INO inosine, MFI mean fluorescence intensity, TMZ temozolomide.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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