FIGURE

Fig. 5

ID

ZDB-FIG-250428-64

Publication

D'Aprile et al., 2025 - Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Guanosine and inosine increase MFN2 expression.

a Heatmap of Z-Score values based on mRNA relative expression of 7 genes, involved in mitochondrial fusion and fission. b–d PCA biplot of 7 genes in CTRL, TMZ-treated and TMZ + GUA + INO-treated cells for U-251 MG S (b), U-251 MG R (c) and T98-G (d). Key-coloured arrows represent the contribution of each variable to the PCA; small circles are the single sample, while large circles are the mean points of the confidence ellipses. e mRNA expression levels of MFN2 in CTRL, TMZ-treated and TMZ + GUA + INO-treated cells for U-251 MG S, U-251 MG R, T98-G. Data are shown via scattered dot plots as mean ± SD of n ≥ 3 independent experiments. ***p-value < 0.001 and ****p-value < 0.0001 between groups. ###p-value < 0.001 and ####p-value < 0.0001 vs CTRL U-251 MG S. CTRL control, GUA guanosine, INO inosine, PCs principal components, PCA principal components analysis, TMZ temozolomide.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.