FIGURE

Fig. 4

ID

ZDB-FIG-250428-63

Publication

D'Aprile et al., 2025 - Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment

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Fig. 4

GBM zebrafish model shows increased purine biosynthesis and reduced purine catabolism.

a RNA-seq analysis of the top 50 GO pathways dysregulated in the zic:RAS zebrafish model. Data are shown as −log₁₀ of FDR. b Summary plot of genes involved in purine dysregulated pathways showed in (a) with the description of their functions. In red are represented functions correlated with biosynthetic processes and in blue functions correlated with catabolic processes. Squares are key-coloured according to their log₂ FC over CTRL. CTRL control, FC fold change, FDR false discovery rate, GO gene ontology.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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