FIGURE

Fig. 2

ID

ZDB-FIG-250428-61

Publication

D'Aprile et al., 2025 - Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Sensitive and resistant GBM cells display distinct metabolic profiles.

a Heatmap of Z-Score values based on the abundance of 38 metabolites. b–d Volcano plots of metabolites levels expressed as log₂ fold changes over CTRL and −log₁₀ of adjusted p-value in U-251 MG S CTRL versus TMZ-treated (b), U-251 MG R CTRL versus TMZ-treated (c), T98-G CTRL versus TMZ-treated (d). White dots represent not significantly modulated metabolites; black dots represent significantly modulated metabolites; green dots represent metabolites showing the same trend in all tested cell lines; orange dots represent metabolites showing the same trend in resistant cell lines (i.e. U-251 MG R and T98-G). Data include n = 4 independent replicates per group. CTRL control, TMZ temozolomide.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.