ZFIN Image: D'Aprile et al., 2025, Fig. 2

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Figure Caption

Fig. 2 Sensitive and resistant GBM cells display distinct metabolic profiles.

a Heatmap of Z-Score values based on the abundance of 38 metabolites. b–d Volcano plots of metabolites levels expressed as log₂ fold changes over CTRL and −log₁₀ of adjusted p-value in U-251 MG S CTRL versus TMZ-treated (b), U-251 MG R CTRL versus TMZ-treated (c), T98-G CTRL versus TMZ-treated (d). White dots represent not significantly modulated metabolites; black dots represent significantly modulated metabolites; green dots represent metabolites showing the same trend in all tested cell lines; orange dots represent metabolites showing the same trend in resistant cell lines (i.e. U-251 MG R and T98-G). Data include n = 4 independent replicates per group. CTRL control, TMZ temozolomide.

Acknowledgments

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