FIGURE

Fig. 4

ID

ZDB-FIG-250221-42

Publication

Counil et al., 2025 - Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Passage of pEVs through bEnd.3 endothelial cells in the presence of HMC3 microglial cells. (a) bEnd.3 cells were cultured on a Transwell for 10 days with HMC3 cells seeded at the bottom, and 1 1010 pEVs/mL were added for 24 h. (b) Uptake of PKH-pEVs (in red, indicated by arrows) by bEnd.3 cells (nuclei in blue, Clau-5 in green, ZO-1 in purple). (c)–(d) Percentage of bEnd.3 cells internalizing PKH-pEVs were quantified by flow cytometry and compared by ordinary one-way ANOVA. Prior statistical analysis, the normality of each data set was evaluated. Data are expressed in mean ± SEM with *p ≤ 0.5; **p ≤ 0.05; ****p ≤ 0.0005 with n ≥ 6 per group. pEVs, peripheral EVs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Extracell Biol