FIGURE

Fig. 8

ID

ZDB-FIG-250221-46

Publication

Counil et al., 2025 - Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation

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Fig. 8

Brain homing of pEVs and their internalization by neuronal cells in the Tg(huc:EGFP) zebrafish. (a) Live confocal images (maximum projection) at 1 hpi and 24 hpi of the head of Tg(huc:EGFP) larvae (20× and 40×) after injection of 4.5 nL of PBS or pEVs (1 1010 pEVs/mL) from either HeC or mAD patients (red, indicated by arrows). Neurons are in green and the nucleus in blue. (b) Three-dimensional reconstruction on Imaris software of the head of the zebrafish 1 and 24 hpi of PKH-pEVs from HeC (20×) and mAD (40×) patients. Neuronal cells are in green, PKH-pEVs are in red, and colocalization areas are in white. (c) The percentage of neurons engulfing PKH-pEVs was quantified by Zen 2.6 software and compared by ordinary one-way ANOVA followed by Tukey's multiple comparisons test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Extracell Biol