FIGURE

Fig. 9

ID

ZDB-FIG-250221-47

Publication

Counil et al., 2025 - Brain penetration of peripheral extracellular vesicles from Alzheimer's patients and induction of microglia activation

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Fig. 9

Brain homing of pEVs and their internalization by glial-like cells in the Tg(gfap:EGFP) zebrafish. (a) Live confocal images (maximum projection) at 1 and 24 hpi of the head of Tg(gfap1:EGFP) larvae (20× and 40×), with pEVs in red (indicated by arrows) and glial-like cells in green. (b) Three-dimensional reconstruction on Imaris software of the head of the zebrafish 1 and 24 hpi of PKH-pEVs from HeC (20×) and mAD (40×) patients. Glial-like cells are in green, PKH-pEVs are in red, and colocalization areas are in white. (c) The percentage of glial-like cells capturing PKH-pEVs was quantified by Zen 2.6 software and compared by ordinary one-way ANOVA followed by Tukey's multiple comparisons test. (d) Three-dimensional reconstruction on Imaris software of PKH-pEVs diffusion into the brain and their internalization by glial-like cells 24 hpi. Prior statistical analysis, the normality of each data set was evaluated. Data are expressed in mean ± SEM **p ≤ 0.05; ***p ≤ 0.005 with n = 7 per group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Extracell Biol