FIGURE

Fig. 9

ID

ZDB-FIG-250219-67

Publication

Dharmadhikari et al., 2025 - RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

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Fig. 9

SPOUT1/CENP-32 bi-allelic variants disrupt centrosome-spindle pole tethering, causing chromosome segregation errors, altering cell cycle progress, and increasing apoptosis in neuronal progenitor cells.

Schematic summarizing the proposed differences between healthy cells and SPOUT1/CENP-32 variant cells leading to aneuploid daughter cells, altered cell cycle/ cell death, and microcephaly in affected individuals and mutant zebrafish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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