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Fig. 9

ID: ZDB-IMAGE-250219-68
Source: Figures for Dharmadhikari et al., 2025

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Figure Caption

Fig. 9 SPOUT1/CENP-32 bi-allelic variants disrupt centrosome-spindle pole tethering, causing chromosome segregation errors, altering cell cycle progress, and increasing apoptosis in neuronal progenitor cells.

Schematic summarizing the proposed differences between healthy cells and SPOUT1/CENP-32 variant cells leading to aneuploid daughter cells, altered cell cycle/ cell death, and microcephaly in affected individuals and mutant zebrafish.

Acknowledgments

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