IMAGE

Fig. 9

ID
ZDB-IMAGE-250219-68
Publication
Dharmadhikari et al., 2025 - RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS
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Figures for Dharmadhikari et al., 2025
Image
Figure Caption

Fig. 9 SPOUT1/CENP-32 bi-allelic variants disrupt centrosome-spindle pole tethering, causing chromosome segregation errors, altering cell cycle progress, and increasing apoptosis in neuronal progenitor cells.

Schematic summarizing the proposed differences between healthy cells and SPOUT1/CENP-32 variant cells leading to aneuploid daughter cells, altered cell cycle/ cell death, and microcephaly in affected individuals and mutant zebrafish.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.
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