FIGURE

Fig. 6

ID

ZDB-FIG-250203-35

Publication

Naef et al., 2025 - Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS

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Fig. 6

ERG response is increased in sacs^-/- larvae. (A) Representative ERG traces at low, medium and maximum light intensity from control (black), sacs^-/- (blue) at 120 hpf. (B) Averaged ERG b-wave amplitudes from control (black), sacs^-/- (blue) larvae. Sacs^-/- mutants produce an increase of the ERG b-wave amplitude compared with control throughout all light intensities tested (*p < 0.05, **p < 0.01). Data were collected from three independent experiments (N = 30 for each group, sacs^-/- and controls). For statistical comparison, a two-way ANOVA test was used. (ns: not significant; SI unit for luminance is candela per square meter (cd/m²)). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sacs^irc1/irc1
Observed In:	detection of light stimulus detection of light stimulus involved in visual perception
Stage:	Day 5

Phenotype Detail

Acknowledgments

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