FIGURE

Fig. 5

ID

ZDB-FIG-250203-34

Publication

Naef et al., 2025 - Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS

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Fig. 5

Sacsin deficiency alters cell fate and photoreceptor structure in zebrafish retina (A) Representative confocal images of the retina of sacs^-/- zebrafish obtained after immunostaining of rods with a rhodopsin antibody (red) and with PKC-α to label bipolar cells. (B) Immunostaining of amacrine cells with a HuC antibody (red). Nuclei were highlighted with DAPI·(C) Analysis of fluorescence mean intensity in knockout larvae compared to controls. (D-F′) Representative confocal images of the retina of sacs^-/- zebrafish obtained after immunostaining of rods with a rhodopsin antibody (red) and cones (Uv-opn1sw and Blue-opn1sw) in green. Scale bar = 50 μm (A-B′) and 10 μm (C-D′). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Expression Data

Antibodies:	Ab1-elavl Ab3-opn1sw1 Ab3-opn1sw2 Ab3-rho Ab5-prkca
Fish:	WT sacs^irc1/irc1
Anatomical Terms:	amacrine cell retinal bipolar neuron retinal cone cell retinal rod cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sacs^irc1/irc1
Observed In:	amacrine cell retina retinal cone cell retinal rod cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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