FIGURE

Fig. 9

ID

ZDB-FIG-240909-19

Publication

Campbell et al., 2024 - p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation

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Fig. 9

Summary model of the temporal NF-kB (p65) regulation of HSPC development and cell cycle.NF-kB activates within ECs to induce ECs to become hemogenic by restricting proliferation. NF-kB is subsequently inactivated, allowing for a proliferative expansion of the HE. Finally, NF-kB is re-activated in HECs to drive EndoMT. When the first NF-kB activity wave is disrupted, HE fails to specify. In contrast, disruption of the second wave of NF-kB activity leads to continued proliferation of the HE pool, preventing their delamination from the DA. Figure 9 created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.