FIGURE

Fig. 9

ID

ZDB-FIG-231208-43

Publication

Claude-Taupin et al., 2023 - The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells

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Fig. 9

YAP reactivation upon chronic kidney disease is correlated with autophagy inhibition.

a Representative images of kidney sections subjected to immunohistochemistry for YAP from controls (n = 5) and patients with diabetic nephropathy (DKD, n = 5) Scale bars, 30 µm. b Quantification of YAP nuclear levels in the renal tubules. Data show the mean ± s.e.m.; n = 5. two-sided t-test. c Representative images of kidney sections subjected to immunohistochemistry for LC3 and LAMP1 from controls and patients with diabetic nephropathy (n = 5) Scale bars, 30 µm. d Quantification of colocalization between LC3 and LAMP1 in the renal tubules. Data show the mean ± s.e.m.; n = 4 (controls) and n = 5 (diabetic nephropathy). two-sided t-test. Source data are provided as a Source Data file.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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