FIGURE

Fig. 3

ID

ZDB-FIG-230913-13

Publication

Simonian et al., 2023 - Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish

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Fig. 3

Food intake and metabolic rate are affected by mthfr deficiency in larvae. (A, B) Representative images of zebrafish intestinal content following feeding with fluorescent paramecia in (A) WT controls and (B) mthfr −/− mutant zebrafish (mthfr −/−, HSC194) at 5 dpf. (C) Food intake, measured by relative CTCF, at 5 dpf in WT compared with mthfr −/− mutants. (D) Relative metabolic rate in WT versus mthfr −/− at 5 dpf. (E, F) Representative images following feeding with fluorescent paramecia in (D) WT and (E) mthfr −/− at 8 dpf. (F) Relative CTCF at 8 dpf in WT compared with mthfr −/− mutants. (G) Relative CTCF at 8 dpf in WT compared with mthfr −/− mutants. (H) Relative metabolic rate in WT versus mthfr −/− at 8 dpf. For all food intake measures: 80× magnification, scale bar = 200 μm, n = 20/group. All values are mean ± SEM. Analyzed by Student’s t-test. Significant at ^*P < 0.05, ^*^*P < 0.01, ^*^*^*P < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.