FIGURE

Fig. 1

ID

ZDB-FIG-230913-11

Publication

Simonian et al., 2023 - Methylenetetrahydrofolate reductase deficiency and high dose FA supplementation disrupt embryonic development of energy balance and metabolic homeostasis in zebrafish

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Fig. 1

mthfr zebrafish model creation and study design. Schematic of the steps to generate (A) 4gRNA mthfr crispant zebrafish and (B) germline mthfr −/− mutant zebrafish (HSC194). (C) Simplified study design. Metabolic analyses included measures of food intake, metabolic rate and lipid accumulation. Analysis indicated by the gray arrowhead was performed following a 10-day HCD challenge. Abbreviations: F0, mutagenized generation; F1 +/−, first-generation zebrafish heterozygous for mthfr; F2 −/−, second-generation zebrafish nullizygous for mthfr; hpf, hours postfertilization; MCFA, medium chain fatty acid; WT, wild-type zebrafish from AB background.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Hum. Mol. Genet.