FIGURE

Fig. 6

ID

ZDB-FIG-230508-69

Publication

Yu et al., 2022 - Changes in aggression and locomotor behaviors in response to zinc is accompanied by brain cell heterogeneity and metabolic and circadian dysregulation of the brain-liver axis

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Fig. 6

Fig. 6. Transcriptional signature of genes related to circadian and metabolic functions in the brain and liver. Signature DEGs associated with insulin functions in the brain (A and B) and liver (C); signature DEGs associated with lipid metabolism in the liver (D); signature DEGs associated with neurodegenerative diseases (aplp2, amyloid beta precursor like protein, E) signature DEGs associated with circadian rhythm in the liver (F); alignment of zebrafish IDE (purple) with human IDE (orange) with the zinc binding pockets shown (zebrafish: yellow; human: green, G); a potential functional integration of circadian and metabolism signatures between the liver and brain (H). In figure G, the SWISS-MODEL of zebrafish IDE to human IDE (PDB ID: 2JG4.1) was used as template.

Expression Data

Genes:	acad11 aplp2 fasn g6pc1a.2 ide il1b irs1 pgd
Fish:	AB
Condition:	chemical treatment by environment: zinc dichloride
Anatomical Terms:	brain liver
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: zinc dichloride
Observed In:	brain brain glucose metabolic process brain lipid metabolic process brain regulation of sensory perception liver liver circadian rhythm liver glucose metabolic process liver lipid metabolic process
Stage:	Adult

Phenotype Detail

Acknowledgments

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