Gene

pgd

ID

ZDB-GENE-040426-2807

Name

phosphogluconate dehydrogenase

Symbol

pgd Nomenclature History

Previous Names

fi03d03 (1)
wu:fi03d03 (1)
zgc:111848
zgc:55585 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable NADP binding activity and phosphogluconate dehydrogenase (decarboxylating) activity. Acts upstream of or within vascular associated smooth muscle cell differentiation. Predicted to be active in cytosol. Is expressed in several structures, including axis; chordo neural hinge; digestive system; sensory system; and solid lens vesicle. Orthologous to human PGD (phosphogluconate dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55585 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Facchinello et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pgd Human Ortholog

No data available

Associated With pgd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR006184	6-phosphogluconate-binding site
Domain	IPR006114	6-phosphogluconate dehydrogenase, C-terminal
Domain	IPR006115	6-phosphogluconate dehydrogenase, NADP-binding
Family	IPR006113	6-phosphogluconate dehydrogenase, decarboxylating
Family	IPR006183	6-phosphogluconate dehydrogenase
Homologous_superfamily	IPR008927	6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Homologous_superfamily	IPR013328	6-phosphogluconate dehydrogenase, domain 2
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily