ZFIN is now using GRCz12tu for Genomic Data
Gene
irs1
- ID
- ZDB-GENE-030131-872
- Name
- insulin receptor substrate 1
- Symbol
- irs1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within cellular response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including digestive system; endocrine system; kidney; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kamei et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7F4P8 | InterPro | 1099 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers