ZFIN is now using GRCz12tu for Genomic Data
Gene
irs1
- ID
- ZDB-GENE-030131-872
- Name
- insulin receptor substrate 1
- Symbol
- irs1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Acts upstream of or within cellular response to hypoxia. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including digestive system; endocrine system; kidney; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; type 2 diabetes mellitus; and uterine fibroid. Orthologous to human IRS1 (insulin receptor substrate 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Kamei et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Insulin receptor substrate | IRS-type PTB domain | PH-like domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|
| UniProtKB:E7F4P8 | InterPro | 1099 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers