Gene
ide
- ID
- ZDB-GENE-070410-85
- Name
- insulin-degrading enzyme
- Symbol
- ide Nomenclature History
- Previous Names
-
- zgc:162603 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be active in cytosol; mitochondrion; and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001431 | Peptidase M16, zinc-binding site |
| Domain | IPR007863 | Peptidase M16, C-terminal |
| Domain | IPR011765 | Peptidase M16, N-terminal |
| Domain | IPR032632 | Peptidase M16, middle/third domain |
| Domain | IPR054734 | Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4 |
| Family | IPR050626 | Peptidase M16 |
| Homologous_superfamily | IPR011249 | Metalloenzyme, LuxS/M16 peptidase-like |
Domain Details Per Protein
| Protein | Length | Coenzyme PQQ synthesis protein F-like, C-terminal lobe, domain 4 | Metalloenzyme, LuxS/M16 peptidase-like | Peptidase M16 | Peptidase M16, C-terminal | Peptidase M16, middle/third domain | Peptidase M16, N-terminal | Peptidase M16, zinc-binding site |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IL71
|
998 | |||||||
|
UniProtKB:A4QP10
|
978 | |||||||
|
UniProtKB:A0A8M2BGX2
|
998 |
Interactions and Pathways
No data available
Plasmids
No data available