Gene

ide

ID
ZDB-GENE-070410-85
Name
insulin-degrading enzyme
Symbol
ide Nomenclature History
Previous Names
  • zgc:162603 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable metal ion binding activity and metallopeptidase activity. Acts upstream of or within pancreas regeneration and type B pancreatic cell development. Predicted to be active in mitochondrion and peroxisomal matrix. Is expressed in myotome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from O'Hare et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ide Human Ortholog
No data available
Associated With ide Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001431 Peptidase M16, zinc-binding site
Domain IPR007863 Peptidase M16, C-terminal
Domain IPR011765 Peptidase M16, N-terminal
Domain IPR032632 Peptidase M16, middle/third domain
Homologous_superfamily IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
Domain Details Per Protein
Protein Length Metalloenzyme, LuxS/M16 peptidase-like Peptidase M16, C-terminal Peptidase M16, middle/third domain Peptidase M16, N-terminal Peptidase M16, zinc-binding site
UniProtKB:A5A8J7 998
UniProtKB:A4QP10 978
UniProtKB:A0A0R4IL71 998
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations