Fig. 14
- ID
- ZDB-FIG-230207-42
- Publication
- Li et al., 2022 - Erianin Controls Collagen-Mediated Retinal Angiogenesis via the RhoA/ROCK1 Signaling Pathway Induced by the alpha2/beta1 Integrin-Collagen Interaction
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Effects of erianin on the RhoA/ROCK1 pathway in vivo. (A) The mRNA levels of rhoa, rock1I, and mypt1 in adult and embryonic zebrafish retinas exposed to normoxia, hypoxia, or erianin at various concentrations. B (B?I) Protein expression of GTP-RhoA, ROCK1, and p-MYPT1 in adult and embryonic zebrafish retinas under normoxia, hypoxia, or erianin at various concentrations. (B?II) Quantitative analysis of GTP-RhoA, ROCK1, and p-MYPT1 in adult and embryonic zebrafish retinas. The results are presented as percentages of the normoxia group. * Significant difference between samples in the adult zebrafish (paired t-test, P values < 0.05) and in the zebrafish embryos (independent sample t-test, P values < 0.05); # Comparison with adult zebrafish induced by low-oxygen without erianin treatment (paired t-test, P values < 0.05) or with zebrafish embryos induced by CoCl2 without erianin treatment (independent sample t-test, P values < 0.05); ? Comparison with normoxic zebrafish embryos without erianin treatment (independent sample t-test, P values < 0.05). |
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Stage Range: | Day 5 to Adult |
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Stage: | Adult |