Gene
rock1
- ID
- ZDB-GENE-100712-2
- Name
- Rho-associated, coiled-coil containing protein kinase 1
- Symbol
- rock1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in epicardial cell to mesenchymal cell transition; negative regulation of adherens junction organization; and positive regulation of stress fiber assembly. Acts upstream of or within regulation of cytoskeleton organization. Predicted to be located in plasma membrane. Predicted to be active in cytoplasmic stress granule and cytoskeleton. Is expressed in forebrain and hindbrain. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR015008 | ROCK, Rho binding domain |
| Domain | IPR037310 | Rho-associated protein kinase 1, HR1 |
| Family | IPR020684 | Rho-associated protein kinase 1/2 |
| Family | IPR050839 | Rho-associated Serine/Threonine Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | C1-like domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Rho-associated protein kinase 1/2 | Rho-associated protein kinase 1, HR1 | Rho-associated Serine/Threonine Kinase | ROCK, Rho binding domain | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PRV2
|
1375 | |||||||||||||
|
UniProtKB:A0A0R4IVY5
|
1359 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available