Gene
tuba1b
- ID
- ZDB-GENE-030822-1
- Name
- tubulin, alpha 1b
- Symbol
- tuba1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within microtubule-based process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including ectoderm; integument; nervous system; neural tube; and pleuroperitoneal region. Orthologous to several human genes including TUBA1C (tubulin alpha 1c).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb944 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tuba1b | N/A | Veldman et al., 2010 |
| MO2-tuba1b | N/A | Veldman et al., 2010 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha tubulin | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A516 | InterPro | 449 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tuba1b-201
(1)
|
Ensembl | 1,588 nt | ||
| mRNA |
tuba1b-202
(1)
|
Ensembl | 1,350 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-18F23 | ZFIN Curated Data | |
| Encodes | EST | cb944 | Thisse et al., 2001 | |
| Encodes | EST | fb22g06 | ZFIN Curated Data | |
| Encodes | EST | fc11g01 | Rauch et al., 2003 | |
| Encodes | EST | fc45a12 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:173992 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_194388 (1) | 1590 nt | ||
| Genomic | GenBank:BX465853 (1) | 220945 nt | ||
| Polypeptide | UniProtKB:B8A516 (1) | 449 aa |
- Ferlazzo, G.M., Gambetta, A.M., Amato, S., Cannizzaro, N., Angiolillo, S., Arboit, M., Diamante, L., Carbognin, E., Romani, P., La Torre, F., Galimberti, E., Pflug, F., Luoni, M., Giannelli, S., Pepe, G., Capocci, L., Di Pardo, A., Vanzani, P., Zennaro, L., Broccoli, V., Leeb, M., Moro, E., Maglione, V., Martello, G. (2023) Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity. Nature communications. 14:39623962
- Huang, S., Zhang, H., Chen, W., Su, N., Yuan, C., Zhang, J., Xiang, S., Hu, X. (2023) CRISPR/Cas9-Mediated Knockout of tnfaip1 in Zebrafish Plays a Role in Early Development. Genes. 14(5):
- Suzuki, H., Ogawa, T., Fujita, S., Sone, R., Kawahara, A. (2023) Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis. Scientific Reports. 13:1227912279
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Maffioli, E., Angiulli, E., Nonnis, S., Grassi Scalvini, F., Negri, A., Tedeschi, G., Arisi, I., Frabetti, F., D'Aniello, S., Alleva, E., Cioni, C., Toni, M. (2022) Brain Proteome and Behavioural Analysis in Wild Type, BDNF+/- and BDNF-/- Adult Zebrafish (Danio rerio) Exposed to Two Different Temperatures. International Journal of Molecular Sciences. 23(10)
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Xu, Y., Liu, J., Tian, Y., Wang, Z., Song, Z., Li, K., Zhang, S., Zhao, H. (2022) Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging. International Journal of Molecular Sciences. 23(19):
- Gu, J., Guo, M., Huang, C., Wang, X., Zhu, Y., Wang, L., Wang, Z., Zhou, L., Fan, D., Shi, L., Ji, G. (2021) Titanium dioxide nanoparticle affects motor behavior, neurodevelopment and axonal growth in zebrafish (Danio rerio) larvae. The Science of the total environment. 754:142315
- Gyimah, E., Xu, H., Dong, X., Qiu, X., Zhang, Z., Bu, Y., Akoto, O. (2021) Developmental neurotoxicity of low concentrations of bisphenol A and S exposure in zebrafish. Chemosphere. 262:128045
- Hu, F., Zhao, Y., Yuan, Y., Yin, L., Dong, F., Zhang, W., Chen, X. (2021) Effects of environmentally relevant concentrations of tris (2-chloroethyl) phosphate (TCEP) on early life stages of zebrafish (Danio rerio). Environmental Toxicology and Pharmacology. 83:103600
1 - 10 of 96
Show