FIGURE

FIG 11

ID

ZDB-FIG-220305-44

Publication

Romartinez-Alonso et al., 2021 - Structure-guided approach to relieving transcriptional repression inResistance to Thyroid Hormone α

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FIG 11

In vivo analysis of TRα target genes. (A and B) Expression of thyroid hormone receptor target genes (KLF9 and Dio3b) in WT and E403X mutant TRα-injected zygotes exposed to vehicle (DMSO), T3, or ES08. Results are expressed as fold changes versus DMSO-treated cells. *, P < 0.05; **, P < 0.01 for comparison with vehicle-treated embryos. (C) Expression KLF9 (a thyroid hormone receptor target gene) in inducible pluripotent stem cells derived from patient harboring an E403X TRα mutation, with increasing concentrations of T3 or ES08 analogue. Results are expressed as fold changes versus nontreated cells: *, P < 0.05; **, P < 0.01 for comparison of E403X with T3 versus E403X with ES08.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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