FIGURE

FIG 4

ID

ZDB-FIG-220305-37

Publication

Romartinez-Alonso et al., 2021 - Structure-guided approach to relieving transcriptional repression inResistance to Thyroid Hormone α

Other Figures

All Figure Page

Back to All Figure Page

FIG 4

Comparison of wild-type and P393GX LBD structures. (A) Schematic representation of the P393GX LBD with alpha-helices (squares), beta-strands (arrowheads), and specific features of the P393GX mutant compared to the wild-type (highlighted in yellow). (B and C) Wild-type (B) and P393GX (C) LBD structures showing significantly different regions colored differently, with wild-type (purple) and P393GX (yellow). (D and E) Comparison of the wild-type (D) and P393GX (E) ligand-binding pockets, showing the different orientation of His 381 and different positions and interactions of Arg 384 residues. Key residues and helices are labeled with dashed lines denoting polar contacts.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cell. Biol.