ZFIN Image: Romartinez-Alonso et al., 2021, FIG 11

Image

Figure Caption

FIG 11 In vivo analysis of TRα target genes. (A and B) Expression of thyroid hormone receptor target genes (KLF9 and Dio3b) in WT and E403X mutant TRα-injected zygotes exposed to vehicle (DMSO), T3, or ES08. Results are expressed as fold changes versus DMSO-treated cells. *, P < 0.05; **, P < 0.01 for comparison with vehicle-treated embryos. (C) Expression KLF9 (a thyroid hormone receptor target gene) in inducible pluripotent stem cells derived from patient harboring an E403X TRα mutation, with increasing concentrations of T3 or ES08 analogue. Results are expressed as fold changes versus nontreated cells: *, P < 0.05; **, P < 0.01 for comparison of E403X with T3 versus E403X with ES08.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mol. Cell. Biol.