FIGURE

Figure 9

ID

ZDB-FIG-211112-9

Publication

Okasato et al., 2021 - An ATX-LPA₆-Gα₁₃-ROCK axis shapes and maintains caudal vein plexus in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 9

Schematic diagram of the expected function of ATX-LPA₆-Gα₁₃-ROCK axis in CVP formation

LPA produced by ATX activates the LPA₆ receptor on endothelial cells, which induces actin stress fiber formation via Gα₁₃, RhoA, and ROCK pathway. Actin stress fiber formation is then stimulated and contributes to (1) activation of Yap transcription factor leading to sprouting angiogenesis via β-catenin and Notch signaling pathways, (2) generation of contractile forces on ECs in developing plexus vessels leading to vessel subdivision and separation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ iScience